Relationship of transcriptional markers to Leydig cell number in the mouse testis

Title: Relationship of transcriptional markers to Leydig cell number in the mouse testis
Creator: Rebourcet, Diane; Monteiro, Ana; Cruickshanks, Lyndsey; Jeffery, Nathan; Smith, Sarah; Milne, Laura; O'Shaughnessy, Peter J.; Smith, Lee B.
Relation: PL o S One Vol. 14, Issue 7, no. e0219524
Publisher Link: http://dx.doi.org/10.1371/journal.pone.0219524
Publisher: Public Library of Science (PLoS)
Resource Type: journal article
Date: 2019
Description: Objectives: The current study aims to identify markers that would reflect the number of Leydig cells present in the testis, to help determine whether labour-intensive methods such as stereology are necessary. We used our well-characterised Sertoli cell ablation model in which we have empirically established the size of the Leydig cell population, to try to identify transcriptional biomarkers indicative of population size. Results: Following characterisation of the Leydig cell population after Sertoli cell ablation in neonatal life or adulthood, we identified Hsd3b1 transcript levels as a potential indicator of Leydig cell number with utility for informing decision-making on whether to engage in time-consuming stereological cell counting analysis.
Subject: transcriptional markers; Leydig cells; testis; stereological cell counting
Identifier: http://hdl.handle.net/1959.13/1444081
Identifier: uon:42192
Identifier: ISSN:1932-6203
Language: eng
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